I was reminded the other day of an interesting quote from a 2000 FEBS paper which starts with:
“How highly would one rate an economic analysis of a factory that ignored the consumer demand for its products? Ludicrous as it may sound, this is precisely what most metabolic studies of the past century have been doing.”
FEBS Lett. 2000 Jun 30;476(1-2):47-51.Regulating the cellular economy of supply and demand. Hofmeyr JS, Cornish-Bowden A.