Monthly Archives: March 2013

Choke points, Load points, Hots spots and Key steps

Choke points, load points, hot spots, key steps and critical steps are some of the many phrases that have been coined to describe places in a biochemical network where perturbations are said to make a difference. Locating these places is … Continue reading

Posted in Enzyme Kinetics, General Science Interest, Metabolic Control Analysis, Modeling, Molecular Biology, Pathways, Systems Theory | Leave a comment

Irreversible Bistability

Last week I was in need of an irreversible bistable switch to show my class. I remember seeing one in the well known review by Tyson et al, Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in … Continue reading

Posted in General Science Interest, Modeling, Pathways, SBML, Software, Systems Theory | Leave a comment

Michael Savageau’s Book in Print Again

I’ve been meaning to mention this for some time but Michael Savageau book, ‘Biochemical Systems Analysis’ is available in print again in the form of a paperback from amazon for only $29.95. I grew up with this book as an … Continue reading

Posted in Enzyme Kinetics, Metabolic Control Analysis, Systems Theory, Textbooks | Leave a comment