I’ve been meaning to mention this for some time but Michael Savageau book, ‘Biochemical Systems Analysis’ is available in print again in the form of a paperback from amazon for only $29.95. I grew up with this book as an undergraduate and graduate. Its about systems biology before systems biology became popular in the 2000s. It’s a mine of information about how systems work. For example I particularly like the proof that tell us the strength of feedback necessary for a given pathway length that leads to oscillations. In a lot of respects the analysis is very similar to metabolic control analysis but what is nice about Savageau’s approach is that he deals far more with the dynamical side of systems, something that is missing from MCA.
Although originally published in 1976, his book can still teach us a lot about how systems operate.