Category Archives: Metabolic Control Analysis

Reversibility and Product Inhibition

It is common in biochemistry to categorize reactions as either reversible or irreversible. What do we mean by these terms? Let’s look at a simple reaction such as:     where A is transformed to B. The rate of reaction … Continue reading

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Bottlenecks and Slow Steps – again

I’ve written a few articles on this blog about the irrationality of bottlenecks and slow steps in metabolism, hoping that one day my fellow scientists will feel the same. Sadly it is not true and maybe I should write more … Continue reading

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Choke points, Load points, Hots spots and Key steps

Choke points, load points, hot spots, key steps and critical steps are some of the many phrases that have been coined to describe places in a biochemical network where perturbations are said to make a difference. Locating these places is … Continue reading

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Michael Savageau’s Book in Print Again

I’ve been meaning to mention this for some time but Michael Savageau book, ‘Biochemical Systems Analysis’ is available in print again in the form of a paperback from amazon for only $29.95. I grew up with this book as an … Continue reading

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Misconceptions in Metabolism II

A week ago I wrote about some misconceptions in metabolism that arose from a trip to a systems biology workshop in Holland. This week I discovered that Nature is perpetrating similar misconceptions in their News and Views section. I came … Continue reading

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Misconceptions in Metabolism

I’m currently at the ISGSB meeting (International Study group for Systems Biology – formally BTK) in Holland. This is a group that values both¬†theoretical¬†analysis and experimentation in biochemical network analysis. Its an interesting group of people that I have literally … Continue reading

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Ludicrous as it may sound

I was reminded the other day of an interesting quote from a 2000 FEBS paper which starts with: “How highly would one rate an economic analysis of a factory that ignored the consumer demand for its products? Ludicrous as it … Continue reading

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Jim Burns’ Ph.D Thesis

Why on earth should anyone would want to download a Ph.D thesis that is now almost 40 years old and presumably way out of date and completely irrelevant in today’s terabyte data world? Well for one, Jim’s thesis is an … Continue reading

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Biochemical Control Analyis 101: Part 2

What is a control coefficient? First we should indicate what we mean by control. The term control has a special meaning in biochemical control analysis. Control refers to the ability of a system parameter to affect a system variable. For … Continue reading

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Metabolic Control Analyis 101: Part 1

What is Metabolic Control Analysis? Broadly speaking, Metabolic Control Analysis is a mathematical approach that allows us to understand and quantify how perturbations to a biochemical pathway propagate out from the disturbance to the rest of the system. Metabolic Control … Continue reading

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