Category Archives: Metabolic Control Analysis

Misconceptions in Metabolism II

A week ago I wrote about some misconceptions in metabolism that arose from a trip to a systems biology workshop in Holland. This week I discovered that Nature is perpetrating similar misconceptions in their News and Views section. I came … Continue reading

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Misconceptions in Metabolism

I’m currently at the ISGSB meeting (International Study group for Systems Biology – formally BTK) in Holland. This is a group that values both¬†theoretical¬†analysis and experimentation in biochemical network analysis. Its an interesting group of people that I have literally … Continue reading

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Ludicrous as it may sound

I was reminded the other day of an interesting quote from a 2000 FEBS paper which starts with: “How highly would one rate an economic analysis of a factory that ignored the consumer demand for its products? Ludicrous as it … Continue reading

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Jim Burns’ Ph.D Thesis

Why on earth should anyone would want to download a Ph.D thesis that is now almost 40 years old and presumably way out of date and completely irrelevant in today’s terabyte data world? Well for one, Jim’s thesis is an … Continue reading

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Biochemical Control Analyis 101: Part 2

What is a control coefficient? First we should indicate what we mean by control. The term control has a special meaning in biochemical control analysis. Control refers to the ability of a system parameter to affect a system variable. For … Continue reading

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Metabolic Control Analyis 101: Part 1

What is Metabolic Control Analysis? Broadly speaking, Metabolic Control Analysis is a mathematical approach that allows us to understand and quantify how perturbations to a biochemical pathway propagate out from the disturbance to the rest of the system. Metabolic Control … Continue reading

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